Simple, economic, sensitive and reproducible and rapid spectrophotometric and chromatographic methods have been developed and validated for the determination of Telmisartan (TR) and Paliperidone (PP) in tablets and as bulk drug. The methods applied were involing use Ferric Chloride (FeCl3). The method employs Ferric chloride reagent in presence of hydrochloric acid and Potassium ferricyanide to form greenish complex with λ max at 610 nm and 580 nm for Telmisartan (TR) and Paliperidone (PP) respectively. The concentration of Telmisartan (TR) and Paliperidone (PP) over a range of 10-60 μg/ml was found sufficient for obeying Beer’s law in the stated range. The results of the analysis have been validated statistically and by recovery studies.
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